Tenofovir diphosphate – CAS 166403-66-3

Characterisation

CAS: 166403-66-3, 2738719-07-6 (Na⁺ salt), 2122333-63-3 (Et₃NH⁺ salt)

IUPAC Name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

Other names: Tenofovir diphosphate, PMPA-diphosphate, PMPApp

Molecular weight: 447.17 g/mol

Molecular formula: C₉H₁₆N₅O₁₀P₃

InChI: InChI=1S/C9H16N5O10P3/c1-6(2-14-4-13-7-8(10)11-3-12-9(7)14)22-5-25(15,16)23-27(20,21)24-26(17,18)19/h3-4,6H,2,5H2,1H3,(H,15,16)(H,20,21)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1

Description

Tenofovir diphosphate is a metabolite of tenofovir. Tenofovir is a nucleotide analog reverse-transcriptase inhibitor (NtRTI). It selectively inhibits viral reverse transcriptase, a crucial enzyme in retroviruses such as human immunodeficiency virus (HIV), while showing limited inhibition of human enzymes, such as DNA polymerases α, β, and mitochondrial DNA polymerase γ.

References

• https://doi.org/10.1089/aid.2012.0089
• https://doi.org/10.1128/AAC.01710-17
• https://doi.org/10.1128/AAC.42.3.612

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