Characterisation

CAS: 152502-95-9, 207128-24-3 (Et₃NH⁺ salt)

IUPAC Name: 1-​[2-​deoxy-​5-​O-​[hydroxy[[hydroxy(ph​osphonooxy)​phosphinyl]​oxy]​phosphinyl]​-​β-​L-​erythro-​pentofuranosyl]​-​5-​methyl-2,​4(1H,​3H)​-​pyrimidinedione

Other names: Telbivudine triphosphate, Telbivudine TP

Molecular weight: 428.17 g/mol,

Molecular formula: C₁₀ H₁₇ N₂ O₁₄ P₃

Storage: -20 °C, protect from light, stored under argon

We are providing Telbivudine triphosphate in the form of Et₃NH⁺ salt.

Description

Telbivudine triphosphate is synthesised by Pure Chems.

Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (European Union) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. However, HBV signature resistance mutation M204I (a change from methionine to isoleucine at position 204 in the reverse transcriptase domain of the hepatitis B polymerase) or L180M+M204V have been associated with Telbivudine resistance.

Telbivudine is a synthetic thymidine β-L-nucleoside analogue; it is the L-isomer of thymidine. Telbivudine impairs hepatitis B virus (HBV) DNA replication by leading to chain termination. It differs from the natural nucleotide only with respect to the location of the sugar and base moieties, taking on a levorotatory configuration versus a dextrorotatory configuration as do the natural deoxynucleosides

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