BDP FL maleimide – CAS 773859-49-7

Characterisation

CAS: 773859-49-7

IUPAC Name: 3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.0^3,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)-N-[2-(2,5-dioxopyrrol-1-yl)ethyl]propanamide

Other names: BDP FL maleimide, F01-0013, BP-22550

Molecular weight: 414.2 g/mol

Molecular formula: C₂₀H₂₁BF₂N₄O₃

InChI: InChI=1S/C20H21BF2N4O3/c1-13-11-14(2)26-17(13)12-16-4-3-15(27(16)21(26,22)23)5-6-18(28)24-9-10-25-19(29)7-8-20(25)30/h3-4,7-8,11-12H,5-6,9-10H2,1-2H3,(H,24,28)

Solubility: Good in organic solvents (DMF, DMSO, dichloromethane), limited in water

Excitation/absorption maximum: 503 nm

Emission maximum: 509 nm

Description

Introducing Thiol-reactive BDP FL maleimide, a dynamic dye engineered for efficient protein labeling.

Derived from the borondipyrromethene family, BDP FL maleimide shares absorption and fluorescence spectra characteristics with fluorescein (FAM). What sets this dye apart is its exceptional photostability, making it an ideal choice for a variety of applications. With a non-charged nature and low molecular weight, BDP FL maleimide matches the brightness of fluorescein, R110, and xanthene dye derivatives.

This versatile fluorophore finds its excellence in fluorescent microscopy and various other applications. Offering a seamless substitution for fluorescein across a wide range of applications, BDP FL maleimide is compatible with any FAM-capable fluorescent instrumentation, making it a valuable addition to your research toolkit. Elevate your experiments with the superior qualities of thiol-reactive BDP FL maleimide.

References

• Buecheler JW, Winzer M, Tonillo J, Weber C, Gieseler H. Impact of Payload Hydrophobicity on the Stability of Antibody-Drug Conjugates. Mol Pharm. 2018;15(7):2656-2664. doi:10.1021/acs.molpharmaceut.8b00177

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