3′,4′-Didehydro-3′-deoxyadenosine

Characterisation

CAS: 42867-61-8

IUPAC Name: 3′,4′-Didehydro-3′-deoxyadenosine

Other names: DdhA, Ddh-A

Molecular weight: 249.23 g/mol

Molecular formula: C₁₀H₁₁N₅O₃

InChI: InChI=1S/C10H11N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h1,3-4,6,10,16-17H,2H2,(H2,11,12,13)/t6-,10-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyadenosine is an analogue of adenosine. A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

• https://doi.org/10.1021/ja0013780
• https://doi.org/10.1016/j.tetlet.2010.10.117

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