3′,4′-Didehydro-3′-deoxyuridine diphosphate – CAS 2499590-41-7

Characterisation

CAS: 2499590-41-7

IUPAC Name: ((4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl trihydrogen diphosphate

Other names: DdhU-DP, Ddh-U diphosphate, 3′,4′-Didehydro-3′-deoxyuridine diphosphate

Molecular weight: 386.15 g/mol

Molecular formula: C₉H₁₂N₂O₁₁P₂

InChI: InChI=1S/C9H12N2O11P2/c12-6-3-5(4-20-24(18,19)22-23(15,16)17)21-8(6)11-2-1-7(13)10-9(11)14/h1-3,6,8,12H,4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/t6-,8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyuridine diphosphate is a metabolite of 3′,4′-Didehydro-3′-deoxyuridine (DdhU). A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

• WO2020202142 A2 2020-10-08
• https://doi.org/10.1016/j.tetlet.2010.10.117
• US3457255 A 1969-07-22
• WO2022038539 A2 2022-02-24

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