3′,4′-Didehydro-3′-deoxythymidine monophosphate

Characterisation

CAS: N.A.

IUPAC Name: ((R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,5-dihydrofuran-2-yl)methyl dihydrogen phosphate

Other names: DdhT-MP, Ddh-T-MP,

Molecular weight: 304.19 g/mol

Molecular formula: C₁₀H₁₃N₂O₇P

InChI: InChI=1S/C10H13N2O7P/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(19-8)5-18-20(15,16)17/h2,4,8H,3,5H2,1H3,(H,11,13,14)(H2,15,16,17)/t8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxythymidine monophosphate is a metabolite of 3′,4′-Didehydro-3′-deoxythymidine (DdhT). A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

• WO2020202142 A2 2020-10-08

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