3′,4′-Didehydro-3′-deoxyadenosine triphosphate– CAS 2761971-65-5

Characterisation

CAS: 2761971-65-5

IUPAC Name: ((4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl tetrahydrogen triphosphate

Other names: DdhA-TP, Ddh-A-TP, 3′,4′-Didehydro-3′-deoxyadenosine triphosphate, DdhA triphosphate

Molecular weight: 489.17 g/mol

Molecular formula: C₁₀H₁₄N₅O₁₂P₃

InChI: InChI=1S/C10H14N5O12P3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,3-4,6,10,16H,2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t6-,10+/m0/s1

Description

3′,4′-Didehydro-3′-deoxyadenosine triphosphate is a metabolite of is 3′,4′-Didehydro-3′-deoxyadenosine (DdhA). A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

• WO2022038539 A2 2022-02-24
• https://doi.org/10.1021/ja0013780
• https://doi.org/10.1016/j.tetlet.2010.10.117

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